Bhatia S (2017) Nanotechnology in drug delivery: fundamentals, design, and applications. CRC
Press
Bhavsar MD, Tiwari SB, Amiji MM (2006) Formulation optimization for the nanoparticles-in-
microsphere hybrid oral delivery system using factorial design. J Control Release 110(2):
422–430
Boles MA, Ling D, Hyeon T, Talapin DV (2016) The surface science of nanocrystals. Nat Mater 15:
141
Centre for Drug Evaluation Taiwan (2017) Regulatory considerations for nanotechnology-related
drug products in Taiwan. https://www.pmda.go.jp/files/000151972.pdf. Accessed 10 Apr 2019
Chauhan MK, Bhatt N (2019) Bioavailability enhancement of polymyxin B with novel drug
delivery: development and optimization using quality-by-design approach. J Pharm Sci 108:
1521–1528
Chavan RB, Modi SR, Bansal AK (2015) Role of solid carriers in pharmaceutical performance of
solid supersaturable SEDDS of celecoxib. Int J Pharm 495(1):374–384
Chaves LL, Costa LSA, Vieira AC, Barreiros L, Segundo MA, Ferreira D et al (2017) pH-sensitive
nanoparticles for improved oral delivery of dapsone: risk assessment, design, optimization and
characterization. Nanomedicine 12(16):1975–1990
Cheng R, Meng F, Deng C, Zhong Z (2015) Bioresponsive polymeric nanotherapeutics for targeted
cancer chemotherapy. Nano Today 10(5):656–670
Chopra D, Gupta KC, Sharma S, Katri M, Singh B, Singh B (2015) Nanostructured drug delivery:
toxicological challenges and safety issues. In: Singh B, Kanwar JR, Katare OP (eds)
Nanomedicine, vol vol 1. Studium Press LLC, USA, pp 493–535
Chung NO, Lee MK, Lee J (2012) Mechanism of freeze-drying drug nanosuspensions. Int J Pharm
437(1–2):42–50
Cochran WC, Cox GM (1992) Experimental design. Wiley, New York
Crommelin DJA, Storm G, Jiskoot W, Stenekes R, Mastrobattista E, Hennink WE (2003)
Nanotechnological approaches for the delivery of macromolecules. J Control Release 87:81–88
Cun D, Jensen DK, Maltesen MJ, Bunker M, Whiteside P, Scurr D et al (2011) High loading
efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: quality by
design optimization and characterization. Eur J Pharm Biopharm 77(1):26–35
Dadkhah D, Navarchian AH, Aref L, Tavakoli N (2014) Application of Taguchi method to
investigate the drug release behavior of poly(acrylamide-co-maleic acid)/montmorillonite
nanocomposite hydrogels. Adv Polym Technol 33(4):1–9
Danhier F, Préat V, Langer R, Anderson DG (2017) Nanoparticle-based drug delivery systems: a
commercial and regulatory outlook as the field matures. Expert Opin Drug Deliv 14(7):851–864
Das B, Sen SO, Maji R, Nayak AK, Sen KK (2017) Transferosomal gel for transdermal delivery of
risperidone: formulation optimization and ex vivo permeation. J Drug Deliv Sci Tec 38:59–71
De Crozals G, Bonnet R, Farre C, Chaix C (2016) Nanoparticles with multiple properties for
biomedical applications: a strategic guide. Nano Today 11(4):435–463
Department of Biotechnology Indian Society of Nanomedicine (2019) Guidelines for evaluation of
nanopharmaceuticals in India. http://www.dbtindia.nic.in/wp-content/uploads/Modified-
Guidelines-for-Evaluation-of-Nanopharmaceuticals-in-India-converted-2.pdf.
Accessed
23
Mar 2019
Dhoble S, Patravale V (2019) Development of anti-angiogenic erlotinib liposomal formulation for
pulmonary hypertension: a QbD approach. Drug Deliv Transl Res 9(5):980–996
Djuris J, Djuric Z (2017) Modeling in the quality by design environment: regulatory requirements
and recommendations for design space and control strategy appointment. Int J Pharm 533(2):
346–356
Durakovic B (2017) Design of experiments application, concepts, examples: state of the art. PEN
5(3):421–439
El-Say KM, Hosny KM (2018) Optimization of carvedilol solid lipid nanoparticles: an approach to
control the release and enhance the oral bioavailability on rabbits. PLoS One 13(8):1–15
344
B. Singh et al.